The Seattle Mariners will look to win their eighth game in a row when they take on the Baltimore Orioles in a key American League matchup on Tuesday. The Mariners (66-53), who are 9-1 in their past 10 games, are 29-28 on the road this season. The Orioles (53-65), who are fifth in the AL East, are 28-29 on their home field in 2025.

First pitch from Oriole Park at Camden Yards in Baltimore is set for 6:35 p.m. ET. The Orioles have won six of the past seven meetings with the Mariners. Seattle is a -158 favorite on the money line (risk $158 to win $100) in the latest Mariners vs. Orioles odds from DraftKings Sportsbook, while the total number of runs Vegas thinks will be scored, or the over/under, is 9 in the latest MLB odds. 

Before you make any Mariners vs. Orioles picks or MLB predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 21 of the 2025 MLB season a profitable 31-23 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning nearly 60 units of profit. Anybody following could have seen strong returns!

The model has simulated Mariners vs. Orioles 10,000 times and the results are in. We can tell you the model is going Over on the run total, and it also says one side of the money line has all the value!

Who wins Mariners vs. Orioles, and which side of the money line has all the value? ... Join SportsLine right now to find out which side of the money line you should be all over, all from the model on a 31-23 roll on top-rated MLB money-line picks!