Mariners vs. Guardians odds, line, prediction: Proven MLB model reveals Sunday Night Baseball picks

The first Sunday Night Baseball game of the 2026 MLB season will see a pair of divisional winners from last year facing off as the Cleveland Guardians visit the Seattle Mariners. Cleveland (2-1) won the AL Central with an 88-74 record before bowing out in the Wild Card Round. Seattle (1-2) clinched the AL West with a 90-72 mark before falling in seven games in the ALCS. Emerson Hancock (4-5, 4.90 ERA) will start for the Mariners, with Slade Cecconi (7-7, 4.30 ERA) going for the Guardians.

First pitch is at 7:20 p.m. ET from T-Mobile Park in Seattle. The latest Guardians vs. Mariners odds list Seattle as the -144 favorite on the money line (risk $144 to win $100). The over/under for total runs is 7.5.

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The model has simulated Guardians vs. Mariners 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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