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LSU vs. Vanderbilt prediction, odds, best bets: Week 8, 2025 college football picks from proven model

SportsLine's model has locked in its Vanderbilt vs. LSU best bets for Saturday's SEC showdown

ByPublished: Oct 18, 2025 2:35PM UTC . 2 min read

One of five ranked matchups during college football Week 8 will see the No. 10 LSU Tigers visiting the 17th-ranked Vanderbilt Commodores on Saturday. This is the first ranked meeting between the teams since 1947. LSU (5-1, 2-1 SEC) is coming off a 20-10 victory over South Carolina, with the Tigers' lone loss of the year coming versus Ole Miss. Vanderbilt (5-1, 1-1 SEC) had a bye last week but dropped its only game of the season the week prior, falling to Alabama, 30-14.

Kickoff is at noon ET from FirstBank Stadium in Nashville, Tenn. The Commodores are 2.5-point favorites in the latest Vanderbilt vs. LSU odds, while the over/under for total points scored is 47.5. Vanderbilt is at -124 on the money line (risk $124 to win $100), while LSU is priced at +104 (risk $100 to win $104).

Before making any LSU vs. Vanderbilt picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 39-27 combined on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

The model has simulated Vanderbilt vs. LSU 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in nearly 70% of simulations!

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Ross Kelly

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