LSU vs. Ole Miss odds, line, best bets: Week 5, 2025 college football picks from proven model
SportsLine's model has locked in its Ole Miss vs. LSU best bets for Saturday's SEC showdown
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A pair of top-15-ranked SEC teams will square off on Saturday afternoon as the No. 4 LSU Tigers visit the No. 13 Ole Miss Rebels. The Tigers (4-0, 1-0) are coming off a 56-10 victory over Southeastern, which followed a win over Florida in their SEC opener. The Rebels (4-0, 2-0) won back-to-back conference games over Kentucky and Arkansas before knocking off Tulane, 45-10, in Week 4. LSU prevailed when these teams met last season, taking a home contest, 29-26, in overtime.
Kickoff is at 3:30 p.m. ET from Vaught-Hemingway Stadium in Oxford, Miss. The Rebels are 2-point favorites in the latest Ole Miss vs. LSU odds, while the over/under for total points scored is 57.5. Ole Miss is at -129 on the money line, while LSU is priced at +109.
Before making any LSU vs. Ole Miss picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 35-22 combined on money-line and over/under college football picks since the beginning of 2024. Anyone following could have seen impressive returns.
The model has simulated Ole Miss vs. LSU 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 60% of simulations!
So who wins LSU vs. Ole Miss, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the Ole Miss vs. LSU spread you need to jump on, all from the computer model that has crushed its college football picks!
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Written by Ross Kelly
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