LSU vs. No. 4 Alabama odds, line: 2025 college football picks for Week 11 predictions from proven model

The LSU Tigers take on the fourth-ranked Alabama Crimson Tide in a key Southeastern Conference matchup on Saturday night. LSU is coming off a 49-25 loss to Texas A&M on Oct. 25, while Alabama defeated South Carolina 29-22 that same day. The Tigers (5-3, 2-3 SEC), who are 10th in the conference, are 1-2 on the road this year. The Crimson Tide (7-1, 5-0 SEC), who are tied for first in the league, have won seven consecutive games. They are 4-0 at home.

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Kickoff from Bryant-Denny Stadium in Tuscaloosa, Ala., is at 7:30 p.m. ET. Alabama leads the all-time series 57-27-5, including a 15-10 edge in Tuscaloosa. The Crimson Tide are 10.5-point favorites in the latest LSU vs. Alabama odds, while the over/under for total points scored is 49.5 via SportsLine consensus. 

Before making any LSU vs. Alabama picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anyone following could have seen impressive returns.

The model has simulated LSU vs. Alabama 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in over 60% of simulations.

So who wins LSU vs. Alabama, and which side of the spread hits over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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