LSU vs. Michigan odds, lines: Proven model reveals college basketball picks for the 2021 NCAA Tournament second-round matchup

The eighth seeded LSU Tigers meet the top-seeded Michigan Wolverines in an NCAA Tournament Round of 32 matchup Monday on CBS. Tip-off from Lucas Oil Stadium in Indianapolis is set for 7:10 p.m. ET. William Hill Sportsbook lists Michigan as a five-point favorite, while the Over-Under for total points scored is 148 in the latest LSU vs. Michigan odds (see up-to-date lines for every game on our college basketball odds page). 

Before making any LSU vs. Michigan picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,500 for $100 players on its top-rated college basketball picks against the spread. It has also returned almost $500 on all top-rated college basketball picks this season. Anyone who has followed it has seen HUGE returns.

Now, it has set its sights on LSU vs. Michigan. We can tell you the model is leaning Over the total, and it also says one side of the spread hits well over 50 percent of the time! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins LSU vs. Michigan? And which side of the spread hits well over 50 percent of the time? ... Join SportsLine right now to find out which side of the LSU vs. Michigan spread you should be all over Monday, all from the model on a roll on college basketball picks!