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LSU vs. Florida prediction, odds, spread, start time: 2025 college football picks, Week 3 best bets from proven model

SportsLine's model has locked in its CFB predictions and best bets for Saturday's No. 3 LSU Tigers vs. Florida Gators game

ByPublished: Sep 13, 2025 10:19PM UTC . 2 min read

The LSU Tigers (2-0) and Florida Gators (1-1) will begin their SEC schedules when they meet on Saturday night. LSU upset Clemson on the road in Week 1 before defeating Louisiana Tech, 23-7, last Saturday. Meanwhile, the Gators easily handled Long Island University in their opener before falling to South Florida, 18-16, in Week 2, also falling out of the AP Top 25. Florida defeated LSU last season, which ended a five-game win streak by the Tigers in the series.

Kickoff is at 7:30 p.m. ET from Tiger Stadium in Baton Rouge, La. The Tigers are 6.5-point favorites in the latest Florida vs. LSU odds, while the over/under for total points scored is 47.5.

Before making any LSU vs. Florida picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 31-19 combined on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

The model has simulated Florida vs. LSU 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it also says one side of the spread hits in almost 60% of simulations!

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Ross Kelly

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