Louisville vs. Syracuse odds, line, spread: Proven model reveals college football picks, predictions for Week 11, 2021

An ACC battle is on tap between the Louisville Cardinals and the Syracuse Orange at noon ET on Saturday at Cardinal Stadium. U of L is 4-5 overall and 3-2 at home, while 'Cuse is 5-4 overall and 2-1 on the road. The Orange are ranked fourth in the Atlantic Division; the Cardinals are ranked fifth. 

The Cardinals are favored by three points in the latest Louisville vs. Syracuse odds from Caesars Sportsbook, and the over-under is set at 55.5. Before you make any Syracuse vs. Louisville picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 11 of the 2021 season on a 31-20 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Louisville vs. Syracuse 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Louisville vs. Syracuse? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!