Louisville vs. SMU odds, prediction: 2026 ACC men's college basketball picks from proven model

A pair of teams in the middle of the ACC standings will collide on Tuesday's college basketball schedule as the Louisville Cardinals visit the SMU Mustangs. No. 21 Louisville (19-6, 8-4 ACC) is tied for sixth in the conference and is riding a five-game win streak. SMU (17-8, 6-6 ACC) slots eighth in the ACC and is coming off a Saturday defeat to Syracuse. The Cardinals have won all four previous meetings.

Tipoff is at 7 p.m. ET from the Moody Coliseum in Dallas. The Cardinals are 3.5-point favorites in the latest SMU vs. Louisville odds from DraftKings Sportsbook, while the over/under for total points scored is 166.5.

Before making any Louisville vs. SMU picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 13-7 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated SMU vs. Louisville 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits 60% of the time!

So who wins Louisville vs. SMU, and which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the SMU vs. Louisville spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!