Louisville vs. SMU odds, line: 2024 college football picks, Week 6 predictions from proven model

The No. 22 Louisville Cardinals will try to bounce back from their first loss of the season when they host the SMU Mustangs on Saturday afternoon. Louisville had its three-game winning streak snapped in a 31-24 loss at then-No. 16 Notre Dame last week. SMU wrapped up a four-game homestand with blowout wins over TCU and Florida State, scoring 42 points in the win over the Seminoles. 

Kickoff is set for noon ET on Saturday at L&N Federal Credit Union Stadium. Louisville is favored by 6.5 points in the latest Louisville vs. SMU odds, while the over/under is 56.5 points, per SportsLine consensus. Before entering any SMU vs. Louisville picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of well over $2,000 for $100 players on its top-rated college football picks against the spread.  It also went a sizzling 6-0 on all top-rated college football picks in Week 5. Anyone who has followed it has seen STRONG returns.

The model has simulated Louisville vs. SMU 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in 60% of simulations. You can only see the pick at SportsLine.

So who wins Louisville vs. SMU? And which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.