Louisville vs. Notre Dame odds, line: 2023 college football picks, Week 6 predictions from proven model

The No. 25 Louisville Cardinals will try to remain unbeaten when they host the No. 10 Notre Dame Fighting Irish on Saturday night. Louisville was able to keep its perfect record alive when it got past NC State in a 13-10 final last week. Notre Dame bounced back from a narrow loss to then-No. 6 Ohio State with a 21-14 win over then-No. 17 Duke to keep its College Football Playoff hopes alive. 

Kickoff is set for 7:30 p.m. ET on Saturday at L&N Federal Credit Union Stadium in Louisville. Notre Dame is favored by 6.5 points in the latest Louisville vs. Notre Dame odds, while the over/under is set at 54 points, per SportsLine consensus. 

Before entering any Notre Dame vs. Louisville picks, you NEED to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of more than $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model has simulated Louisville vs. Notre Dame 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in over 50% of simulations. You can only see the pick at SportsLine.

So who wins Notre Dame vs. Louisville? And which side of the spread is hitting over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks. If you're already a member, see the picks below!