The second-ranked Miami (Fla.) Hurricanes look to stay perfect on the season when they battle the Louisville Cardinals in an Atlantic Coast Conference matchup on Friday night. Louisville is coming off a 30-27 overtime loss to Virginia on Oct. 4, while Miami defeated Florida State 28-22 that same night. The Cardinals (4-1, 1-1 ACC), who are 0-1 against ranked opponents, are 1-0 on the road this season. The Hurricanes (5-0, 1-0 ACC), who are 2-0 against unranked opponents, are 4-0 on their home field in 2025.

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Kickoff from Hard Rock Stadium in Miami Gardens, Fla., is at 7 p.m. ET. Miami leads the all-time series 11-4-1, but Louisville has won four of the last six, including a 38-31 decision in 2023. The Hurricanes are 11.5-point favorites in the latest Louisville vs. Miami odds, while the over/under for total points scored is 49.5 via SportsLine consensus. 

Before making any Louisville vs. Miami picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 39-27 combined on money-line and over/under picks since the beginning of 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Louisville vs. Miami 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Louisville vs. Maimi, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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