Louisville vs. Duke odds, prediction: 2026 Atlantic Coast Conference men's college basketball picks from proven model

The No. 23 Louisville Cardinals take on the fifth-ranked Duke Blue Devils in a key Atlantic Coast Conference matchup on Monday night. Louisville is coming off an 85-71 win over Virginia Tech on Saturday, while Duke downed Wake Forest 90-69 that same day. The Cardinals (14-5, 4-3 ACC), who are tied for sixth in the conference, are 2-3 on the road this season. The Blue Devils (18-1, 7-0 ACC), who are 6-1 against ranked opponents, are 9-0 on their home court.

Tip-off from Cameron Indoor Stadium in Durham, N.C., is set for 7 p.m. ET. Duke leads the all-time series 18-9, including a 5-3 edge in games at Durham. Duke is an 8.5-point favorite in the latest Louisville vs. Duke odds from DraftKings Sportsbook, while the over/under for total points scored is 157.5. 

Before making any Louisville vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 13 on a sizzling 10-1 run on top-ranked over/under picks dating back to last year, and it is on a 6-0 roll on side picks. Anyone following could have seen HUGE returns!

The model has simulated Louisville vs. Duke 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits over 50% of the time!

So who wins Louisville vs. Duke, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!