Louisville vs. Cincinnati line, picks: Advanced college football computer model reveals selections for Fenway Bowl matchup

The Louisville Cardinals and Cincinnati Bearcats resume their rivalry when they meet in the inaugural Fenway Bowl on Saturday. Cincinnati (9-3) owns a 30-22-1 record in the all-time series with Louisville (7-5) but has lost the last two contests in overtime, with the most recent contest being a 31-24 setback in 2013. The Fenway Bowl finally makes its debut after being canceled each of the last two years due to COVID-19 issues. Both teams will be playing under an interim coach and with backup quarterbacks, so there are a lot of betting angles to consider in this one.

Kickoff at Fenway Park in Boston is scheduled for 11 a.m. ET. The Cardinals are 2-point favorites in the latest Louisville vs. Cincinnati odds at Caesars Sportsbook, while the over/under for total points scored is set at 38.5 (see up-to-date odds for every game this week on our college football odds page). 

Before making any Cincinnati vs. Louisville picks, you NEED to check out the college football predictions from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Louisville lost two of its last three regular-season games, including a 26-13 setback at Kentucky in its finale on Nov. 26. The Cardinals are tied for 19th in the nation with an average of 20.2 points allowed while ranking second in sacks (43) and third in turnovers gained (28). Redshirt sophomore running back Jawhar Jordan is coming off a career-best effort as he posted his third 100-yard performance in four contests, rushing for 145 on 22 carries against Kentucky.

The model also knows Cincinnati had its three-game winning streak halted with a 27-24 loss to Tulane in its regular-season finale on Nov. 25. The Bearcats have lost five of their last seven bowl appearances, including a 27-6 defeat against Alabama in last year's Cotton Bowl - which served as a CFP semifinal game. Charles McClelland leads the team with 834 rushing yards and fellow senior Ryan Montgomery tied career highs with 95 yards and two touchdowns against Tulane.

Now, it has set its sights on Louisville vs. Cincinnati. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in almost 60% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Louisville vs. Cincinnati in the 2022 Fenway Bowl? And which side of the spread hits in almost 60% of simulations? ... Join SportsLine right now to find out which side of the Cincinnati vs. Louisville spread you should be all over Saturday, all from the model on a roll on college football picks!