Louisiana vs. Arkansas State odds, line: 2025 college football picks for Week 13 predictions from proven model

Teams on the fringe of the Sun Belt Conference West Division title chase clash when the Louisiana Ragin' Cajuns face the Arkansas State Red Wolves on Thursday night. Louisiana is coming off a 42-39 win over Texas State on Nov. 8, while Arkansas State dropped a 27-21 decision to Southern Mississippi that same day. The Ragin' Cajuns (4-6, 3-3 SUN), who have won two in a row, are 1-4 on the road this season. The Red Wolves (5-5, 4-2 SUN), who have won four of five, are 3-2 on their home field in 2025. Arkansas State is 7-3 versus the spread this season, while Louisiana is 5-5 against the line.

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Kickoff from Centennial Bank Stadium in Jonesboro, Ark., is at 7:30 p.m. ET. Louisiana leads the all-time series 30-22-1, but Arkansas State holds a 13-11-1 edge in games played in Jonesboro. The Red Wolves are 2.5-point favorites in the latest Louisiana vs. Arkansas State odds, while the over/under for total points scored is 53.5 via SportsLine consensus.

Before making any Louisiana vs. Arkansas State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is profitable on its top-rated money-line and over/under picks since the beginning of the 2024 season. Anyone following could have seen impressive returns.

The model has simulated Louisiana vs. Arkansas State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits well over 60% of simulations.

So who wins Louisiana vs. Arkansas State, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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