Lions vs. Vikings prediction, line, odds: Proven model releases NFL picks, best bets for Christmas Day matchup

The middle matchup of a 2025 NFL Christmas Day tripleheader pits the Detroit Lions versus the Minnesota Vikings. Detroit (8-7) has lost two in a row, including a 29-24 outcome versus Pittsburgh in Week 16. Minnesota (7-8) has won three straight, most recently a 16-13 victory over the New York Giants. The Vikings lead the all-time series, 81-45-2. RB Jordan Mason is inactive, and J.J. McCarthy (hand) will not play as Max Brosmer will make his second career start. Amon-Ra St. Brown (knee) is listed as active, while OL Taylor Decker is inactive.

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW. 

Kickoff is from U.S. Bank Stadium in Minneapolis at 4:30 p.m. ET. The latest Lions vs. Vikings odds have Detroit as the 7-point favorites. The over/under for total points scored is 44.5.

Before making any Vikings vs. Lions picks or NFL predictions, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 17 on a 53-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Lions vs. Vikings on Christmas Day.

We can tell you the model is going Over the point total, but also says one side of the spread is the better value! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Vikings vs. Lions on Christmas, and which side of the spread is the better value? ... Join SportsLine RIGHT NOW to see which side of the Lions vs. Vikings line to back, all from the model that is 53-37 on top-rated picks since 2024!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month for $1 JOIN NOW.