Lions vs. Vikings prediction, line, odds: Proven model releases NFL picks, best bets for Christmas Day matchup

The middle matchup of a 2025 NFL Christmas Day tripleheader pits the Detroit Lions versus the Minnesota Vikings. Detroit (8-7) has lost two in a row, including a 29-24 outcome versus Pittsburgh in Week 16. Minnesota (7-8) has won three straight, most recently a 16-13 victory over the New York Giants. The Vikings lead the all-time series, 81-45-2.

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Kickoff is from U.S. Bank Stadium in Minneapolis at 4:30 p.m. ET. The latest Lions vs. Vikings odds have Detroit as the 6-point favorites. The over/under for total points scored is 44.5.

Before making any Vikings vs. Lions picks or NFL predictions, you NEED to see which side the proven SportsLine projection model is on.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 16 on a 52-37 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!

Now, the model has locked in another confident pick for Lions vs. Vikings on Christmas Day.

We can tell you the model is going Over the point total, but also says one side of the spread hits over 50% of the time! You ABSOLUTELY NEED to see which side to back before locking in any picks of your own.

So who wins Vikings vs. Lions on Christmas, and which side of the spread hits in over 50% of simulations? ... Join SportsLine RIGHT NOW to see which side of the Lions vs. Vikings line to back, all from the model that is 52-37 on top-rated picks since 2024!

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