Lions vs. Eagles prediction, odds, line, spread: Proven model reveals NFL picks, best bets for Week 1, 2022

The Detroit Lions host the Philadelphia Eagles to open the 2022 NFL season for both teams at 1 p.m. ET on Sunday at Ford Field. The Lions were featured on HBO's Hard Knocks and will be looking to notch their first winning season since 2017. The Eagles have high expectations in 2022, and will once again be led by quarterback Jalen Hurts. Philadelphia ended last year second in the NFC East, while the Lions finished fourth in the NFC North. 

Philadelphia is favored by 5.5 points in the latest Lions vs. Eagles odds from Caesars Sportsbook, and the over/under is set at 48.5. Before you make any Eagles vs. Lions picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn't missed a top-rated pick since Week 15 last season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Lions vs. Eagles 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick where one side has all the value. You absolutely need to see it before locking in your own picks.

So who wins Lions vs. Eagles? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.