The NFL preseason will begin on Thursday when the Detroit Lions take on the Los Angeles Chargers in the 2025 Pro Football Hall of Fame Game. It's the first taste of football in nearly six months and, while starters tend to play sparingly, it will undoubtedly draw scores of NFL bettors out of hibernation. The Lions are coming off a 15-2 season where they took the No. 1 seed in the NFC while the Chargers went 11-6 to finish second in the AFC West, but both teams failed to win a postseason game and will be hoping to take another step towards title contention in 2025.

Kickoff from Tom Benson Hall of Fame Stadium in Canton, Ohio, is set for 8 p.m. ET. Detroit is a 1.5-point favorite in the latest Lions vs. Chargers odds, while the over/under for total points scored is 33.5. Before making any Chargers vs. Lions picks or 2025 Pro Football Hall of Fame Game predictions of your own, you NEED to see which side SportsLine NFL expert Matt Severance is on.

Severance is a well-connected writer and high-volume handicapper who has worked in the industry since 2005. He went 121-93-2 for a profit of $589 on his NFL spread picks last season. He's also an amazing 37-12 (+1938) on his last 49 NFL money line picks! Anybody following him could be WAY UP!

Now, Severance has locked in another confident money-line pick for Lions vs. Chargers at the Pro Football Hall of Fame Game 2025.

We can tell you he's leaning Under the point total, but he also knows a crucial X-factor makes one side of the money line a MUST-BACK! You ABSOLUTELY NEED to see what it is before locking in any picks of your own.

So who wins Lions vs. Chargers in the 2025 Pro Football Hall of Fame Game? ... Join SportsLine RIGHT NOW to see which side of the Chargers vs. Lions ML to take, all from the expert who is an AMAZING 37-12 on NFL money-line picks!