Lions vs. 49ers odds, line, spread: Proven model reveals NFL picks, predictions for Week 1, 2021

The Detroit Lions will take on the San Francisco 49ers at 1 p.m. ET on Sunday at Ford Field. The 49ers fell to 6-10 last year after winning the NFC Championship the previous season. The Lions posted their third consecutive losing record at 5-11. 

San Francisco is favored by 8.5 points in the latest Lions vs. 49ers odds from Caesars Sportsbook, and the over-under is set at 46. Before you make any 49ers vs. Lions picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

Now, it has simulated Lions vs. 49ers 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Lions vs. 49ers? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks... If you're already a member, see the picks below!