The Colorado Buffaloes (2-4, 0-3) are set to host the No. 22 Iowa State Cyclones (5-1, 2-1) in a Big 12 showdown on Saturday. Kickoff at Folsom Field in Boulder is scheduled for 3:30 p.m. ET. The Buffs are looking to bounce back from a 35-21 loss to TCU and snap a two-game losing streak. The Cyclones are looking to rebound from their 38-30 loss to Cincinnati on Oct. 4, which was their first loss of the season. Iowa State is 3-2-1, while CU is 3-3 against the spread in 2025.

Iowa State is a 3-point favorite in the latest Colorado vs. Iowa State odds, while the over/under for total points scored is 51.5. Iowa State is a -145 (risk $145 to win $100) favorite on the money line, with Colorado listed as a +120 underdog (see up-to-date odds for every game this week on our college football odds page). 

Before you make any Iowa State vs. Colorado picks or any other college football predictions, you NEED to see which side proven SportsLine expert Jimmie Kaylor is on. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor has destroyed the sportsbooks in college football the last two seasons, posting a 249-175-7 record since Week 1 of the 2023 season. His 2024 college football futures picks included Travis Hunter winning the Heisman at 40-1 odds, bringing his net profit up to a whopping 99.84 units ($9,983.50 for a $100 bettor) since joining SportsLine as an expert in 2023.

All of his picks have been featured on his SportsLine expert page or in his weekly bylined articles. Anyone who followed his picks could be way up.

Now, Kaylor has locked in a confident against-the-spread pick for Colorado vs. Iowa State in their Week 7 matchup. We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Iowa State vs. Colorado in their Week 7 matchup at Folsom Field in Boulder and what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the spread to jump on, all from the expert who is 249-175-7, returning $9,984 for $100 bettors, betting on college football since 2023, and find out!

Be sure to follow Jimmie (@jimmiekaylor) on Twitter for notifications about picks changes/updates