Lakers vs. Spurs prediction, odds, line: Proven model reveals 2026 NBA picks for Jan. 7

A Western Conference matchup on Wednesday's NBA schedule has the Los Angeles Lakers visiting the San Antonio Spurs. The Lakers (23-11) have won three in a row, including a 111-103 victory over New Orleans on Tuesday. San Antonio (25-11) has lost back-to-back outings, including a 106-105 defeat to Memphis on Tuesday. The teams have split their two meetings this season. LeBron James (sciatica, foot) and Victor Wembanyama (knee) are both questionable for San Antonio.

Tipoff is at 9:30 p.m. ET from Frost Bank Center in San Antonio. The latest Lakers vs. Spurs odds list San Antonio as the 7.5-point favorite, while the over/under is 235.5. 

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Before making any Spurs vs. Lakers picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 12 of the 2025-26 NBA season on a sizzling 33-15 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Lakers vs. Spurs 10,000 times and the results are in. The model is going Under on the point total, and it also says one side of the spread hits in well over 50% of simulations!

Who wins Spurs vs. Lakers, and which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the Lakers vs. Spurs spread you should be all over, all from the model on a 33-15 roll on top-rated NBA spread picks!

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