Lakers vs. Pistons odds, line: Proven model reveals picks for NBA matchup on December 30

A cross-conference matchup on Tuesday's NBA schedule has the Detroit Pistons visiting the Los Angeles Lakers. Detroit (24-8) has the best record in the Eastern Conference but is coming off back-to-back losses. The Lakers (20-10) are the current No. 5 seed in the West and defeated Sacramento on Sunday to end a three-game losing streak. Detroit swept the season series a year ago, which ended a Lakers' seven-game win streak in their head-to-head matchups.

Tip-off is at 10:30 p.m. ET from Crypto.com Arena in Los Angeles. Detroit is a 2.5-point favorite in the latest Lakers vs. Pistons odds from SportsLine consensus, while the over/under for total points scored is 232.5. 

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Before making any Lakers vs. Pistons picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight seasons. The model enters Week 11 of the 2025-26 NBA season on a sizzling 32-14 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Pistons vs. Lakers 10,000 times and the results are in. We can tell you that the model is going Under on the point total, and it also says one side of the spread hits in over 50% of simulations!

Who wins Lakers vs. Pistons, and which side of the spread hits over 50% of the time? ... Join SportsLine right now to find out which side of the Pistons vs. Lakers spread you should be all over, all from the model on a 32-14 roll on top-rated NBA picks!

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