Knicks vs. Nets odds, line: Proven model reveals NBA picks for matchup on Wednesday, January 21

NBA Rivals Week 2026 features a crosstown showdown on Wednesday's schedule as the Brooklyn Nets visit the New York Knicks. The Nets (12-29) have lost two in a row and seven of their last eight contests. The Knicks (25-18) have dropped four straight as both squads are struggling. New York leads the all-time series 118-112 and has won 12 straight matchups.

Tip-off is set for 7:30 p.m. ET from Madison Square Garden in New York City. The latest Nets vs. Knicks odds from DraftKings Sportsbook have New York as 11.5-point favorites, while the over/under for total points scored is 220.5. Before making any Knicks vs. Nets picks, you NEED to see what the SportsLine Projection Model has to say.

SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 14 of the 2025-26 NBA season on a sizzling 35-15 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Nets vs. Knicks 10,000 times and the results are in. We can tell you that the model is going Over on the point total, and it also says one side of the spread hits in well over 50% of simulations!

Who wins Knicks vs. Nets, and which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the Nets vs. Knicks spread you should be all over, all from the model on a 35-15 roll on top-rated NBA picks!