Kentucky vs. South Carolina odds, prediction: 2026 Southeastern Conference men's college basketball picks from proven model

The Kentucky Wildcats look to snap a three-game losing streak when they take on the South Carolina Gamecocks in a Southeastern Conference matchup on Tuesday night. Kentucky is coming off a 75-74 loss at Auburn on Saturday, while South Carolina downed Mississippi State 97-89 that same day. The Wildcats (17-10, 8-6 SEC), who are tied for sixth in the conference, are 3-5 on the road this season. The Gamecocks (12-15, 3-11 SEC), who are tied for 13th in the league, are 11-6 on their home floor.

Tip-off from Colonial Life Arena in Columbia, S.C., is set for 7 p.m. ET. Kentucky leads the all-time series 55-15, including 21-10 at Columbia. Kentucky is a 5.5-point favorite in the latest Kentucky vs. South Carolina odds from DraftKings Sportsbook, while the over/under for total points scored is 148.5. 

Before making any Kentucky vs. South Carolina picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Kentucky vs. South Carolina 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 50% of the time!

So who wins Kentucky vs. South Carolina, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!