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Kentucky vs. Michigan State odds, prediction: 2025 Champions Classic picks from proven model

SportsLine's model has locked in its best bets for Michigan State vs. Kentucky in an NCAA men's basketball matchup on Tuesday night

ByPublished: Nov 18, 2025 9:27PM UTC . 2 min read

The No. 17 Michigan State Spartans take on the No. 12 Kentucky Wildcats at the 2025 Champions Classic on Tuesday. The Wildcats are 4.5-point favorites in the latest Michigan State vs. Kentucky odds, while the over/under for total points scored is 152.5.

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Before making any Michigan State vs. Kentucky picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,000 in betting profit for $100 players on its top-rated college basketball picks over the past three seasons. Anyone following could have seen HUGE returns!

The model has simulated Michigan State vs. Kentucky 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread is the better value.

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Daniel Kohn
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