Kansas vs. Iowa State odds, prediction: 2026 Big 12 Conference men's college basketball picks from proven model

Top-10 teams clash when the No. 9 Kansas Jayhawks battle the fifth-ranked Iowa State Cyclones in a key Big 12 Conference matchup on Saturday. Kansas is coming off an 82-78 win over top-ranked Arizona on Monday, while Iowa State dropped a 62-55 decision at TCU on Tuesday. The Jayhawks (19-5, 9-2 Big 12), who have won eight in a row, are 4-3 on the road this season. The Cyclones (21-3, 8-3 Big 12), who are 2-0 against ranked opponents, are 13-0 on their home court.

Tipoff from the Hilton Coliseum in Ames, Iowa, is set for 1 p.m. ET. Kansas leads the all-time series 191-69, including an 84-63 win on Jan. 13. Iowa State is a 7.5-point favorite in the latest Kansas vs. Iowa State odds from DraftKings Sportsbook, while the over/under for total points scored is 146.5. 

Before making any Kansas vs. Iowa State picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 15 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 11-5 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Kansas vs. Iowa State 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits nearly 60% of the time!

So who wins Kansas vs. Iowa State, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!