Kansas vs. Houston odds, prediction: 2026 Big 12 Tournament men's college basketball picks from proven model

The three-seeded Kansas Jayhawks (23-9, 12-6 Big 12) will face two-seeded Houston Cougars (27-5, 14-4 Big 12) in the second semifinal on Friday after defeating TCU 78-72 in the quarterfinals. The Houston Cougars took down BYU 73-66 in the quarterfinals Friday night. These two teams will meet for the second time this season; the Jayhawks won the first matchup 69-56 on February 24. Darryn Peterson, the potential No. 1 overall pick in the NBA draft, scored 24 points in a season-high 37 minutes on Thursday night at T-Mobile Center. 

Tip-off from T-Mobile Center in Kansas City, Missouri, is set for 9:30 p.m. ET. The all-time series is tied 3-3, while Kansas won the one and only matchup so far this season. Houston is a 5.5-point favorite in the latest Kansas vs. Houston odds from DraftKings Sportsbook, while the over/under for total points scored is 134.5. 

Before making any Houston vs. Kansas picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered conference tournament week on a sizzling 14-2 run on top-ranked over/under picks dating back to last year, and is on an 28-21 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Kansas vs. Houston 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over than 50% of simulations!

So who wins Kansas vs. Houston and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!