Kansas vs. Creighton odds, line, spread: 2022 NCAA Tournament picks, prediction from proven computer model

The No. 1 seed Kansas Jayhawks take on the No. 9 seed Creighton Bluejays in a 2022 NCAA Tournament second round matchup at 2:40 p.m. ET on Saturday. The Jayhawks dominated the Texas Southern Tigers in the first round, while Creighton used a second half surge to knock off San Diego State in overtime. Kansas is favored by 11.5 points at Caesars Sportsbook, while the Over-Under is set at 139.5 (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Kansas vs. Creighton picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Kansas is loaded with a plethora of playmakers, including Ochai Agbaji. The senior guard is averaging 19.4 points and 5.1 rebounds per game. Agbaji leads a Kansas offense that is averaging78.7 points per game, which ranks 23rd in the country. The Jayhawks are also in the top 20 nationally in field-goal percentage (48.16), and they've won four of their last five meetings against an opponent from the Big East.

The model has also taken into account that Creighton enters Saturday's matchup full of confidence after winning 10 of its last 13 games. The Bluejays are led by Ryan Hawkins, who's averaging 13.8 points and 7.8 rebounds per game. Hawkins stuffed the stat sheet in Creighton's victory over San Diego State, finishing with 10 points, eight rebounds, three steals and one assist. 

Now, the model has set its sights on Creighton vs. Kansas. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in 70 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Kansas vs. Creighton? And which side of the spread hits in 70 percent of simulations? ... Join SportsLine right now to find out which side of the Creighton vs. Kansas spread you should be all over, all from the model on a roll on college basketball picks!