Kansas vs. Arizona odds, prediction: 2026 Big 12 Conference men's college basketball picks from proven model

The second-ranked Arizona Wildcats will look to secure at least a share of the Big 12 Conference title when they take on the 14th-ranked Kansas Jayhawks in a key Big 12 Conference matchup on Saturday. Kansas is coming off a 69-56 win over the Houston Cougars on Monday, while Arizona defeated the Baylor Bears 87-80 on Tuesday. The Jayhawks (21-7, 11-4 Big 12), who are 6-4 against ranked opponents, are 5-4 on the road this season. The Wildcats (26-2, 13-2 Big 12), who are 8-2 against ranked foes, are 14-1 on their home court.

Tip-off from McKale Center in Tucson, Ariz., is set for 4 p.m. ET. Kansas leads the all-time series 10-5, including an 82-78 win on Feb. 9. Arizona is an 8.5-point favorite in the latest Kansas vs. Arizona odds from DraftKings Sportsbook, while the over/under for total points scored is 146.5. 

Before making any Kansas vs. Arizona picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Kansas vs. Arizona 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 50% of the time!

So who wins Kansas vs. Arizona, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!