Kansas State vs. Kansas odds, prediction: 2026 Big 12 Conference men's college basketball picks from proven model

Teams looking to close out the Big 12 Conference regular season on a high note meet when the Kansas State Wildcats battle the 14th-ranked Kansas Jayhawks on Saturday. Kansas State is coming off a 65-63 win over West Virginia on Tuesday, while Kansas dropped a 70-60 decision at Arizona State that same night. The Wildcats (12-18, 3-14 Big 12), who are 0-7 against ranked opponents this season, are 1-9 on the road this season. The Jayhawks (21-9, 11-6 Big 12), who have lost two in a row, are 12-2 on their home floor.

Tip-off from Allen Fieldhouse in Lawrence, Kan., is set for 2 p.m. ET on Paramount+. Kansas leads the all-time series 203-97, including a 95-35 edge in games played at Lawrence. Kansas is a 16.5-point favorite in the latest Kansas State vs. Kansas odds from DraftKings Sportsbook, while the over/under for total points scored is 156.5. 

Before making any Kansas State vs. Kansas picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered Week 18 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 23-17 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Kansas State vs. Kansas 10,000 times and the results are in. The model is leaning Under, and it also says one side of the spread hits in nearly 60% of simulations!

So who wins Kansas State vs. Kansas, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!