We've got another exciting Big 12 matchup on the schedule as the Kansas State Wildcats and the Iowa State Cyclones are set to tip at 9 p.m. ET on Wednesday at James H. Hilton Coliseum. Iowa State is 14-4 overall and 11-0 at home, while Kansas State is 14-4 overall and 2-1 on the road. Iowa State is favored by 7.5 points in the latest Iowa State vs. Kansas State odds, and the over/under is 135 points.

Before entering any Kansas State vs. Iowa State picks, you'll want to see the NCAA Basketball predictions from the proven computer model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters Week 12 of the 2023-24 season on a 114-73 roll on all top-rated college basketball picks dating back to last season, returning more than $2,000 for $100 players. It is also off to a sizzling 19-5 start on top-rated spread picks this season. Anyone following has seen huge returns.

The model has simulated Iowa State vs. Kansas State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that hits in 60% of simulations. 

So who wins Iowa State vs. Kansas State, and which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks. If you're already a member, see the picks below!