James Madison vs. Louisville prediction, odds: College football expert reveals 2025 Week 2 picks, analysis

The James Madison Dukes battle the Louisville Cardinals in a Week 2 college football matchup on Friday. James Madison is coming off a 45-10 win over Weber State, while Louisville opened its season with a 51-17 win over Eastern Kentucky. The Dukes, who were 9-4 overall last season, were 3-3 on the road a year ago. The Cardinals, who were also 9-4, are 5-2 on their home field since the start of 2024.

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Kickoff is set for 7 p.m. ET at L&N Federal Credit Union Stadium in Louisville, Ky. Louisville won the only meeting with James Madison, 34-10 in 2022. The Cardinals are 15.5-point favorites in the latest James Madison vs. Louisville odds, while the over/under for total points scored is 55. Louisville is at -690 on the money line (risk $690 to win $100), while James Madison is the +491 underdog (risk $100 to win $491).

Before making any James Madison vs. Louisville picks or college football predictions, you NEED to hear what SportsLine college football expert Mike Tierney has to say.

A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney had a tremendous 2024 college football season in which he finished 62-41 (plus $1,649 for $100 players). He is also 15-5 (+950) in his last 20 picks involving Louisville, and 5-0 (+1500) in his last five James Madison picks. Anyone who has followed him could be WAY up!

Now, Tierney has analyzed James Madison vs. Louisville from every angle and just locked in his picks and predictions.

We can tell you he's leaning Under on the point total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins James Madison vs. Louisville on Friday? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the James Madison vs. Louisville spread to jump on, all from the football expert who was 15-5 in his last 20 Louisville picks, and 5-0 in his last five James Madison picks!

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