Jaguars vs. Colts odds, line, spread: Proven model reveals NFL picks, predictions for Week 2, 2022

An AFC South battle is on tap between the Jacksonville Jaguars and the Indianapolis Colts at 1 p.m. ET on Sunday. Jacksonville opened the season with a loss at Washington, while the Colts had to settle for a tie in their first game at Houston. The Colts are 0-7 overall and against the spread in games at Jacksonville going back to 2015. Sunday's showdown will be televised on CBS and streamed live in select markets on Paramount+ with their MUST-HAVE Premium plan. Plus, you can watch games on ANY device!

You can catch all your local NFL on CBS games on Paramount+, which now has two plans. The Essential Plan costs $4.99 per month to access Paramount's catalog of movies and TV shows with limited advertisements, plus your live local NFL games, international soccer and more. The Premium Plan is $9.99 per month and you can watch your local CBS live stream with no ads, on demand and the ability to download episodes for offline viewing. Both plans come with a free week to start, so sign up now here.

Before you make any Colts vs. Jaguars picks and predictions, you NEED to see what the SportsLine Projection Model is saying.

The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

Now, it has simulated Jaguars vs. Colts 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side cashes in over half of all simulations! You ABSOLUTELY need to see it before locking in your own picks. Don't forget, you may be able to stream the game on Paramount+ on ANY DEVICE!

Who wins Colts vs. Jaguars? And which side of the spread hits more than 50 percent of the time? ... Join SportsLine right now to see which side of the Colts vs. Jaguars spread to jump on, all from the model that has crushed its NFL picks!