The Jacksonville State Gamecocks will look to stay unbeaten in Conference USA play when they take on the Sam Houston Bearkats on Thursday night. Jacksonville State is coming off a 42-25 loss at Southern Mississippi on Sept. 27, while Sam Houston dropped a 37-10 decision at New Mexico State last Thursday. The Gamecocks (2-3, 1-0 C-USA), who are tied for third in the league, are 0-3 on the road this season. The Bearkats (0-5, 0-2 C-USA), who are 12th in the conference, are 0-1 on their home field in 2025. Sam Houston is one of three winless teams left standing in FBS.

Kickoff from Shell Energy Stadium in Houston is at 8 p.m. ET on CBS Sports Network. Jacksonville State leads the all-time series 7-6, including two in a row. The Gamecocks are 7-point favorites in the latest Jacksonville State vs. Sam Houston odds, while the over/under for total points scored is 54.5 via SportsLine consensus. 

Before making any Jacksonville State vs. Sam Houston picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

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The model has simulated Jacksonville State vs. Sam Houston 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in nearly 60% of simulations!

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