The Iowa Hawkeyes will take on the Iowa State Cyclones at 4 p.m. ET on Saturday at Kinnick Stadium. Iowa is seeking a much cleaner offensive performance after sputtering to a 7-3 win over South Dakota State last week. The Hawkeyes are favored by 3.5 points in the latest Iowa vs. Iowa State odds from Caesars Sportsbook, while the over-under is set at 41.5. 

Before you make any Iowa State vs. Iowa picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It enters Week 2 of the 2022 college football season on a 48-37 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated Iowa vs. Iowa State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Iowa vs. Iowa State? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!