Iowa State vs. Arizona odds, prediction: 2026 Big 12 Conference men's college basketball picks from proven model

The No. 2 Arizona Wildcats can clinch the No. 1 seed in the Big 12 with a win over the No. 4 Iowa State Cyclones. Iowa State fell to Texas Tech by a score of  82-73 at Texas Tech on Saturday, while Arizona is coming off a 84-61 win over Kansas that same day. The Cyclones (24-5, 11-5 Big 12), who have won seven of the last 10, are 5-4 on the road this season. The Wildcats (27-2, 14-2 Big 12), who have won eight of their last ten, are 15-1 on their home floor.

Tipoff from McKale Memorial Center in Tucson, Ariz., is set for 9 p.m. ET. Arizona is a 7.5-point favorite in the latest Iowa State vs Arizona odds from DraftKings Sportsbook, while the over/under for total points scored is 149.5. 

Before making any Iowa State vs Arizona picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Iowa State vs Arizona 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits in almost 60% of simulations!

So who wins Iowa State vs Arizona, and which side of the spread hits almost 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!