Indiana vs. Purdue odds, prediction: 2026 Big Ten men's college basketball picks from proven model

A pair of in-state conference rivals will clash on Tuesday's college basketball schedule as the No. 12 Purdue Boilermakers visit the Indiana Hoosiers. The Boilermakers (17-3, 7-2 Big Ten) have dropped back-to-back outings, most recently falling 88-82 to Illinois on Saturday. The Hoosiers (13-7, 4-5 Big Ten) ended a four-game skid on Friday by defeating Rutgers, 82-59. Purdue leads the all-time series 128-93.

Tipoff is at 9 p.m. ET from Simon Skjodt Assembly Hall in Bloomington, Ind. The Boilermakers are 4.5-point favorites in the latest Purdue vs. Indiana odds from DraftKings Sportsbook, while the over/under for total points scored is 150.5. 

Before making any Indiana vs. Purdue picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 13 on a sizzling 10-1 run on top-ranked over/under picks dating back to last year, and it is on a 6-0 roll on side picks. Anyone following could have seen HUGE returns!

The model has simulated Purdue vs. Indiana 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits nearly 60% of the time!

So who wins Indiana vs. Purdue, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the Purdue vs. Indiana spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!