Indiana vs. Penn State odds, line, spread: Proven model reveals college football picks, predictions for Week 10, 2022

A Big Ten battle is on tap between the Indiana Hoosiers and the No. 15 Penn State Nittany Lions at 3:30 p.m. ET next Saturday at Memorial Stadium. Penn State has lost two of its last three games, including a 44-31 setback against No. 2 Ohio State last week. The Nittany Lions are favored by 14 points in the latest Indiana vs. Penn State odds from Caesars Sportsbook, while the over/under is set at 49.5. 

Before you make any Penn State vs. Indiana picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Indiana vs. Penn State 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread has ALL the value. You absolutely need to see it before locking in your own picks.

So who wins Indiana vs. Penn State? And which side of the spread has ALL the value? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.