Indiana vs. Michigan State odds, prediction: 2026 men's college basketball picks for March 1 from proven model

Two Big Ten blue bloods will meet on Sunday on CBS and Paramount+ (sign up here) when the Michigan State Spartans visit the Indiana Hoosiers. No. 13 MSU (23-5, 13-4 Big Ten) has won three straight contests, most recently defeating Purdue on Thursday. The Hoosiers (17-11, 8-9 Big Ten) have dropped three straight contests overall and are coming off a Tuesday loss to Northwestern. The Spartans prevailed, 81-60, when these teams met in Michigan on Jan. 13.

Tipoff is at 3:45 p.m. ET from Assembly Hall in Bloomington, Ind. The Spartans are 3.5-point favorites in the latest Indiana vs. Michigan State odds, while the over/under for total points scored is 144.5.

Before making any Michigan State vs. Indiana college basketball picks, check out the latest college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Indiana vs. Michigan State 10,000 times and the results are in. The model is going Over, and it also says one side of the spread hits 60% of the time!

So who wins Michigan State vs. Indiana, and which side of the spread hits in 60% of simulations? Join SportsLine right now to see which side of the Indiana vs. Michigan State spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!