Indiana vs. Michigan odds, prediction: 2026 Big Ten Conference men's college basketball picks from proven model

The third-ranked Michigan Wolverines will look to stay within striking distance of the Big Ten Conference lead when they battle the Indiana Hoosiers on Tuesday. Indiana is coming off a 74-57 loss to Iowa on Saturday, while Michigan topped Oregon 81-71 that same day. The Hoosiers (12-6, 3-4 Big Ten), who have lost three in a row, are 1-3 on the road this season. The Wolverines (16-1, 6-1 Big Ten), who have won two in a row, are 7-1 on their home court.

Tip-off from Crisler Center in Ann Arbor, Mich., is set for 7 p.m. ET. Indiana leads the all-time series 110-67. Michigan is a 15.5-point favorite in the latest Indiana vs. Michigan odds from DraftKings Sportsbook, while the over/under for total points scored is 161.5.

Before making any Indiana vs. Michigan picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 12 on a sizzling 10-1 run on top-ranked over/under picks. Anyone following could have seen HUGE returns!

The model has simulated Indiana vs. Michigan 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Indiana vs. Michigan, and which side hits in well over 60% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!