Indiana vs. Kentucky odds, prediction: 2025 men's college basketball picks from proven model

The Indiana Hoosiers and Kentucky Wildcats renew their rivalry when they meet in non-conference action on Saturday. Indiana is coming off a 113-72 win over Penn State on Tuesday, while Kentucky downed North Carolina Central 103-67 that same night. The Hoosiers (8-2), who finished ninth in the Big Ten at 10-10 and were 19-13 overall last year, are 0-1 on the road this season. The Wildcats (6-4), who tied for sixth in the SEC at 10-8 and were 24-12 in 2024-25, are 6-1 on their home floor this year.

Tip-off from Rupp Arena in Lexington, Ky., is set for 7:30 p.m. ET. Kentucky leads the all-time series 32-25. Kentucky is a 4.5-point favorite in the latest Indiana vs. Kentucky odds from SportsLine consensus, while the over/under for total points scored is 153.5.

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Before making any Indiana vs. Kentucky picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,000 in betting profit for $100 players on its top-rated college basketball picks over the past three-plus seasons. Anyone following could have seen HUGE returns!

The model has simulated Indiana vs. Kentucky 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in over 50% of simulations!

So who wins Indiana vs. Kentucky, and which side hits in over 50% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!

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