The Illinois Fighting Illini of the Big Ten travel to face the Virginia Cavaliers of the ACC in a high-profile college football showdown Saturday. Kickoff is set for 11 a.m. ET from Scott Stadium.

Illinois (1-1) is looking to bounce back from a 37-30 home loss to UTSA last week, while Virginia (1-0) opened its 2021 college football season with a 43-0 win over William & Mary.

The Cavaliers are 10.5 point favorites and the over-under for total points scored is 55.5 in the latest Caesars Sportsbook odds for Illinois vs. Virginia. Before you make any Illinois vs. Virginia  picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Illinois vs. Virginia 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Illinois vs. Virginia? And which side of the spread hits well over 50 percent of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!