Illinois vs. Missouri odds, line, spread: Proven model reveals college basketball picks, predictions for Dec. 22, 2022

The No. 16 Illinois Fighting Illini will take on the Missouri Tigers at 9 p.m. ET on Thursday at the Enterprise Center in the Braggin' Rights Classic. Illinois snapped a three-game losing streak in the rivalry with its 88-63 win last December. The Fighting Illini are favored by 6.5 points in the latest Illinois vs. Missouri odds from Caesars Sportsbook, while the over/under is set at 153.5. 

Before you make any Missouri vs. Illinois picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. The model enters Week 7 of the 2022-23 college basketball season on a strong 19-12 roll on all-top rated CBB picks, returning more than $200. Anybody who has followed it has seen profitable returns.

Now, it has simulated Illinois vs. Missouri 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Illinois vs. Missouri? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!