Howard vs. Drexel odds, prediction: 2025 men's college basketball picks from proven model

The Howard Bison will look to win their fourth game in a row when they take on the Drexel Dragons on Tuesday morning. Howard is coming off a 61-57 win over Hampton on Saturday, while Drexel dropped a 69-64 decision to La Salle on Dec. 6. The Bison (7-5), who finished fourth in the Mid-Eastern Athletic Conference at 7-7 and were 12-20 overall last season, are 0-3 on the road this year. The Dragons (4-6), who tied for seventh in the Coastal Athletic Association at 9-9 and were 18-15 a year ago, are 3-1 on their home floor in 2025-26.

Tip-off from Daskalakis Athletic Center in Philadelphia is set for 11 a.m. ET. Drexel leads the all-time series 3-0, including a 68-65 win last season. Drexel is a 5.5-point favorite in the latest Howard vs. Drexel odds from SportsLine consensus, while the over/under for total points scored is 139.5.

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Before making any Howard vs. Drexel picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,000 in betting profit for $100 players on its top-rated college basketball picks over the past three-plus seasons. Anyone following could have seen HUGE returns!

The model has simulated Howard vs. Drexel 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in nearly 70% of simulations!

So who wins Howard vs. Drexel, and which side hits in nearly 70% of simulations? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!

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