Houston vs. UCF odds, line: 2025 college football picks for Week 11 predictions from proven model

The Houston Cougars will look to stay in the mix for a spot in the Big 12 Conference Championship Game when they battle the Central Florida Knights in a key matchup dubbed "The Space Game" on Friday night. Houston is coming off a 45-35 loss to West Virginia on Saturday, while UCF dropped a 30-3 decision at Baylor that same day. The Cougars (7-2, 4-2 Big 12), who are tied for fourth in the league, are 4-0 on the road this season. The Knights (4-4, 1-4 Big 12), who are 13th in the conference, are 4-1 on their home field in 2025.

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Kickoff from Acrisure Bounce House in Orlando, Fla., is at 8 p.m. ET. UCF leads the all-time series 8-3, including a 27-13 win in their last meeting in 2023. The Cougars are 1.5-point favorites in the latest Houston vs. UCF odds, while the over/under for total points scored is 47.5 via SportsLine consensus.

Before making any Houston vs. UCF picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anyone following could have seen impressive returns.

The model has simulated Houston vs. UCF 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations.

So who wins Houston vs. UCF, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!

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