Houston vs. Oregon State odds, line: 2025 college football picks for Week 5 predictions from proven model

The Houston Cougars (3-0) travel to play the Oregon State Beavers (0-4) in a non-conference battle on Friday evening. The Cougars have won three consecutive games, defeating Colorado 36-20 in Week 3. The Beavers came off a bad loss, falling 41-7 to No. 6 Oregon on the road in an in-state rivalry. This is the first game between these schools in 55 years. 

Kickoff from Reser Stadium in Corvallis, OR, is at 10:30 p.m. ET. Houston leads the all-time series 2-1, and the Cougars won 19-16 in their last meeting in 1970. The Cougars are 13.5-point favorites in the latest Houston vs. Oregon State odds, while the over/under for total points scored is 47.5 via SportsLine consensus. 

Before making any Houston vs. Oregon State picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 35-22 combined on money-line and over/under picks since the beginning of 2024. Anyone following could have seen impressive returns.

The model has simulated Houston vs. Oregon State 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Houston vs. Oregon State, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!