Houston vs. Oklahoma State odds, prediction: 2026 Big 12 Conference men's college basketball picks from proven model

The seventh-ranked Houston Cougars meet the Oklahoma State Cowboys in a Big 12 Conference regular-season finale on Saturday. Houston is coming off a 77-64 win over Baylor on Wednesday, while Oklahoma State downed Central Florida 111-104 in overtime on Tuesday. The Cougars (25-5, 13-4 Big 12), who are looking to finish alone in second place, are 5-3 on the road this season. The Cowboys (18-12, 6-11 Big 12), who are 13th in the conference, are 14-4 on their home court.

Tip-off from Gallagher-Iba Arena in Stillwater, Okla., is set for noon ET on Paramount+. Oklahoma State leads the all-time series 13-12, including an 8-2 edge in games played in Stillwater. Houston is a 12.5-point favorite in the latest Houston vs. Oklahoma State odds from DraftKings Sportsbook, while the over/under for total points scored is 149.5. 

Before making any Houston vs. Oklahoma State picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered Week 18 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 23-17 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Houston vs. Oklahoma State 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits in well over 60% of simulations!

So who wins Houston vs. Oklahoma State, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!