Houston vs. Kansas odds, prediction: 2026 Big 12 men's college basketball picks from proven model

A pair of ranked Big 12 squads coming off Saturday defeats will meet on Monday's college basketball schedule as the Houston Cougars visit the Kansas Jayhawks. No. 2 Houston (23-4, 11-3 Big 12) has lost two in a row, most recently a 73-66 home defeat to Arizona. No. 8 Kansas (20-7, 10-4 Big 12) is coming off an 84-68 loss to Cincinnati which was the Jayhawks' largest home loss to an unranked team in the Bill Self era.

Tipoff is at 9 p.m. ET from the Allen Fieldhouse in Lawrence, Kan. The Cougars are 2.5-point favorites in the latest Kansas vs. Houston odds from DraftKings Sportsbook, while the over/under for total points scored is 138.5.

Before making any Houston vs. Kansas picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 17 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on a 20-11 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Kansas vs. Houston 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 50% of the time!

So who wins Houston vs. Kansas, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the Kansas vs. Houston spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!