Houston vs. Iowa State odds, prediction: 2026 Big 12 men's college basketball picks from proven model

A top-5 showdown on Monday's college basketball schedule has the Houston Cougars visiting the Iowa State Cyclones. The No. 3 Cougars (23-2, 11-1 Big 12) are riding a six-game win streak and sit atop the Big 12 standings. No. 5 Iowa State (22-3, 9-3) has won six of its last seven and is coming off a double-digit win over No. 9 Kansas. These programs have split four all-time meetings.

Tipoff is at 9 p.m. ET from the Hilton Coliseum in Ames, Iowa. The Coogs won the last meeting in 2025 at home. The Cyclones are 1.5-point favorites in the latest Iowa State vs. Houston odds from DraftKings Sportsbook, while the over/under for total points scored is 134.5.

Before making any Houston vs. Iowa State picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 15 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 11-5 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Iowa State vs. Houston 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits over 50% of the time!

So who wins Houston vs. Iowa State, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the Iowa State vs. Houston spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!