Iowa State vs. Houston odds, line: 2025 college basketball picks, February 22 best bets by proven model

The No. 5 Houston Cougars will aim for their sixth straight win on Saturday afternoon when they host the No. 8 Iowa State Cyclones. Houston holds a two-game lead over No. 19 Arizona for first place in the Big 12 standings after picking up a road win at Arizona State on Tuesday. Iowa State has won four consecutive games, but none of those wins have come against ranked opponents. Curtis Jones (illness) and Keshon Gilbert (muscle strain) have both been ruled out for Iowa State.

Tipoff is set for 2 p.m. ET on Saturday at the Fertitta Center in Houston. Houston is favored by 12.5 points in the latest Iowa State vs. Houston odds, while the over/under is 129.5 points per SportsLine consensus. Before entering any Iowa State vs. Houston picks, you'll want to see the college basketball predictions from the model at SportsLine.

The model simulates every Division 1 college basketball game 10,000 times. It enters Week 16 of the 2024-25 season on a 213-158 betting roll (+1675) on all top-rated college basketball picks dating back to 2023. Anyone following at sportsbooks and on betting apps could have seen HUGE returns.

The model has simulated Iowa State vs. Houston 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins Iowa State vs. Houston? And which side of the spread hits almost 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks.